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| 19-02-2021
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Trimethylglycine (TMG) is a molecule which, structurally, is the amino acid Glycine with three methyl groups attached to it. It is known as a 'betaine' molecule ('betaine' being a category of molecules), but because it was the first dietary betaine discovered (from beetroot) and it is the most popular molecule referred to as a betaine, the terms ‘trimethylglycine’ and ‘betaine’ are. Other claims include DMG as an energy booster and a stress reducer as well as a treatment to control seizures. The supplement apparently lowers blood cholesterol, blood sugar, and blood pressure. The amino acid derivative is also believed to treat symptoms of attention deficit hyperactivity disorder (ADHD) and chronic fatigue syndrome. Trimethylglycine supplement benefit and dosage, by Ray Sahelian, M.D. September 12 2016. Trimethylglycine TMG (also known as betaine), and dimethylglycine DMG, are methyl donors that help in the production of several brain chemicals and hence improve mood, energy, wellbeing, alertness, concentration, and visual clarity. Taking high dosages of TMG can possibly cause fishy odors on the breath or in sweat and urine. However, if you feel the need to supplement with TMG and notice the fishy smell, easyazonlink keywords=”riboflavin” locale=”US” tag=”dmgbiz-20″supplementing with riboflavin at 100mg twice a day may get rid of the smell./easyazonlink.

I heard about DMG and TMG from a friend of mine. She said she's talked to a lot of other parents and kids have seen great improvements by starting one of these. TMG is DMG with an extra methyl group added. Or, that's how I understand it anyway. Some kids have seen good progress with speech and since speech is going very slow with Holden, I decided to ask Dr. David if we could try it. He emailed me back with the doseage info and we started 2 days ago. Apparently the therapuetic dose is around 1000-2000mgs per day. I bought the 175mgs. capsules to start him because we like to start things slow. I'm starting with 1/2 cap twice a day for 3 days. Then increasing by 1 capsule every 3 days, until we reach about 1000mgs. per day.
As with everything and autism, it's a crap shoot. What works for some kids doesn't work for others. What doesn't work for other kids works for yours. If I don't see any improvement at all on the TMG, I'll stop it. So far, he's up to taking:
-Vitamin C
-Calcium
-L-Carnosine
-NuThera Multivitamin
-Folinic Acid
-MB12 shots
-Nystatin

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-Cod Liver Oil
-Licorice Root
-TMG
-Factor 4 probioticsAnd
-Epsom salt baths every night
-Glutathione cream
And, almost all of those have to be given twice a day. So, the poor kid has nothing to eat or drink without having some sort of supplement in it. He's good though - doesn't bat an eye. He proably would if I didn't put anything in his juice! He's think it doesn't taste 'right' by now. Ha.
As far as progress, he's doing well. He's babbling more. Trying so hard to talk. He has developed a sensitivity to loud sounds. He never had this before, so I don't know if it's a problem, or if it's a good thing in that he's becoming more aware of his surroundings, instead of being in his own little world. I can't run the blender or vaccum without a freak out/crying session. He calms down immediately when it's over though. And he doesn't cover his ears, he just cries. Like he's scared. He's even a little 'iffy' when the microwave's on. I'm going to discuss with Dr. David next week when we meet with him to discuss chelation. Our appointment is on the 20th.

Trimethylglycine (TMG), commonly known as betaine, is naturally produced in the body to diminish hazardous homocysteine levels. Researches have suggested that TMG, along with other nutrients, helps to reduce potentially toxic levels of homocysteine a naturally occurring amino acid that can be harmful to blood vessels thereby contributing to the development of heart disease, stroke, and peripheral vascular illness. Trimethylglycine works closely with other methyl donors including choline, vitamin B12,folic acid and SAMe, and is in addition a precursor of carnitine synthesis.

Trimethylglycine helps convert homocysteine to methionine by donating a methyl group. The process is called methylation, because a methyl group detaches from a “donor” molecule and attaches onto the homocysteine molecule, converting this potentially toxic amino acid back into methionine.

Once trimethylglycine work has been completed in decreasing homocysteine levels in the body, it becomes another substance known as DMG (dimethylglycine). In Russia, TMG/DMG is used extensively as an sporty performance enhancer, and it has also become popular among American athletes.

Trimethylglycine Benefits

Trimethylglycine is a important aid to reduce homocysteine production and encourage normal heart and liver function.

Homocysteine

Homocysteine is an amino acid, formed as a result of methionine metabolism. Healthy people, homocysteine is converted back into methionine as part of a closed-loop regulatory mechanism that prevents homocysteine levels from becoming too high. The process is called methylation, because a methyl group detaches from a “donor” molecule and attaches onto the homocysteine molecule, converting this potentially toxic amino acid back into methionine. Having high amounts of homocysteine is related to a higher risk of heart illness and stroke. Also, various researches show that high levels of homocysteine may encourage hardening of the arteries.

Trimethylglycine serves as a methyl donor in a reaction converting homocysteine to methionine. Works with vitamin B-6, folic acid and vitamin B12 to help regulate homocysteine levels. Trimethylglycine (500 mg) was administered to healthy male subjects (19-40 years old) finding homocysteine levels were reduced 4 to 6 hours after intake. Analysts concluded TMG capability to augment L-methionine production decreased homocysteine concentrations. In another study, participants who consumed 360 mg of betaine had, on approximate, 10 percent lower concentrations of homocysteine and 19 percent lower concentrations of Creactive protein than did those who consumed 260 mg.

A 2009 study examined the effect of trimethylglycine on atherosclerotic lesion progression in apolipoprotein e-deficient mice. Compared with mice not treated with trimethylglycine following fourteen weeks, mice receiving 1%, 2%, or 4% TMG had 10.8%, 41%, and 37% less lesion areas, respectively. Trimethylglycine furthermore reduced aortic expression of the inflammatory cytokine, TNF-alpha, in a dose-dependent way. These findings suggest that in addition to its homocysteine lowering effect, trimethylglycine may also exert its anti-plaque property by inhibiting aortic inflammatory responses mediated by TNF-alpha.

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Homocystinuria

Homocystinuria, an inherited condition in which the body cannot break down a certain protein, causing build-up of homocysteine in the blood. This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The Food and Drug Administration (FDA) approved anhydrous trimethylglycine (Cystadane) for the therapy of homocystinuria, a disease caused by abnormally high homocysteine levels at birth.

Liver Health

Trimethylglycine, is a substance known as a methyl donor. Methyl molecule donation is important for liver and cells to function appropriately. In other words, TMG is necessary for ensuring appropriate liver function, cellular replication and detoxification reactions.

Trimethylglycine may remedy in treating hepatitis, alcoholic fatty liver disease and nonalcoholic steatohepatitis. Works with folic acid, vitamin B12, folic acid, SAMe, (S-Adenosyl-L-methionine), and choline in your body to support normal liver health. In a trial, supplementation with betaine (20 g) for 12 months improved signs of liver inflammation in 7 patients with nonalcoholic steatohepatitis, a type of liver inflammation. No important adverse effects were seen.

Foods Containing Trimethylglycine

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Broccoli, beets, spinach, grains, seeds and shellfish contain low amounts of trimethylglycine. But, most trimethylglycine in nutrient is destroyed during cooking or processing, therefore food isn’t a reliable way to get a effective dosage.

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Trimethylglycine Dosage

Trimethylglycine supplements, are available in powder, capsule and tablet forms. These supplements, are manufactured as a byproduct of sugar beet processing. Trimethylglycine is generally taken with vitamin B6, folic acid, and vitamin B12. 6 grams of TMG per day is considered a effective dose in the reduction of high homocysteine levels. Choline (2 grams per day) and trimethylglycine (6 grams per day) have each been shown to lower homocysteine amounts. The maximum safe dosage of TMG supplement has not been determined for pregnant or nursing women, children, or those with severe kidney or liver illness.